My Friend's Little Sister Has It In for Me! poster

My Friend's Little Sister Has It In for Me! (2025)

Name: My Friend's Little Sister Has It In for Me!
Genre: Animation, Comedy
Cast: Haruki Ishiya, Sayumi Suzushiro, Tomori Kusunoki, Soma Saito, Kana Hanazawa

★ 7.3 23m/ep Animation · Comedy Latest: S1 E12

For high schooler Akiteru Oboshi, the whole youthful experience thing—like fun, friendships, and even having a girlfriend—is a complete waste of time. So when his best friend’s sister, Iroha Kohinata, keeps teasing him, Akiteru naturally finds it annoying. She practically lives in his room, she’s always on his bed, she’s just a raging storm of clinginess! Why is she only annoying around him?!

Cast: Haruki Ishiya, Sayumi Suzushiro, Tomori Kusunoki, Soma Saito, Kana Hanazawa
Country: Japan
First aired: October 4, 2025

Seasons

Season 1 · 12 episodes

Season 1 Episodes

1. My Friend's Little Sister Has It In for Me
Akiteru just wants to work toward his future, but his friend's little sister won't allow him any peace.
2. The Cousin I Haven't Seen in Years Is Cold to Me
Now that Mashiro has moved to his school, can Akiteru manage to make her open up to him?
3. Only I Can Be a Pain to My Uncle’s Daughter
Akiteru decides to throw a welcome party for Mashiro, but first he must convince her to attend.
4. My Friend's Little Sister Might Be a Delinquent
Akiteru and Iroha recall how they first met.
5. My Friend's Little Sister Keeps Getting Close to Me
A look back at how Iroha came to be the voice actress for 05th Floor Alliance.
6. My Friend's Little Sister Has It In for My Friend's Enemy
While at the mall with Mashiro and Iroha, Akiteru learns why Mashiro left her old school.
7. The Girl Who Confessed to Me Is Cold to Me in Reality
Akiteru tries to give a proper reply to Mashiro's love confession, but she's brutally cold to him in person.
8. Everyone I Know Is Being Weird With Me
Sumire asks Akiteru for help with a problem that could endanger her future with 05th Floor Alliance.
9. My Fake Girlfriend Gets Tough When I Respond To Her Confession
Akiteru and Iroha head to Otoi's studio to record for the game, but Iroha has ideas of her own.
10. My Friend's Little Sister Only Gets an Apology from Me
Akiteru must clear the air with Iroha to keep 05th Floor Alliance running smoothly.
11. We're Perfect for Training the Drama Club
With 05th Floor Alliance's help, the drama club is ready for the big competition... but then disaster strikes.
12. My Friend's Little Sister Really Does Have It In for Me
Can Akiteru save the drama club and secure 05th Floor Alliance's future?